Effect Of Co-Administration Of Aqueous Extract Of Hibiscus Sabdariffa Linn (Malvaceae) Calyx And Vitamin E On Carbamazepine-Induced Testicular Changes In Adult Wistar Rats

📄 Project Abstract

The antioxidant potential of many flavonoid containing plants is increasingly being exploited in therapy. Hibiscus sabdariffa (HS) is one of the most widely used nutraceuticals used traditionally to combat various illnesses due to its high flavonoid contents. The present study was aimed at evaluating the ameliorative effect of co-administration of HS and vitamin E on sub-chronic carbamazepine (CBZ)-induced alterations in semen characteristics. Thirty young male Wistar rats were divided at random into five groups containing 6 rats per groups. Group I and II were administered normal saline and carbamazepine (20 mg /kg), respectively, while group III was treated with CBZ and aqueous extract of Hibiscus Sabdariffa (200 mg/kg); group IV was treated with CBZ and vitamin E (VE) 30 minutes after treatment with CBZ. The regimens were administered orally by gavage once daily for a period of 8 weeks. At the end of the treatment, four animals from each group were randomly selected and sacrificed b...