EFFECT OF CHRONOMODULATED ARTESUNATE ON RENAL AND HAEMATOLOGICAL TOXICITY IN CISPLATIN-TREATED WISTAR RATS

📄 Project Abstract

Cisplatin is a non-cell-cycle dependent chemotherapeutic agent used in the treatment of several common solid tumours. However, an array of serious toxicities in various organs and systems limit its therapeutic use. Artesunate, a semisynthetic derivative of artemisinin is the recommended treatment by the WHO for severe and complicated malaria in low-transmission areas and in the second and third trimesters of pregnancy. In contrast, animal experiments show considerable toxicity upon administration of artemisinins. When malaria and cancer co-exist, treatment of patients could be challenging due to the burden of disease and possible drug-drug interaction. The present study investigates the effect of 7-day chronomodulated artesunate administration on renal and haematological toxicity in cisplatin-treated rats. Four groups (n=7/group) of rats received intraperitoneal (i.p.) injection of 3 mg/kg daily dosing of cisplatin at four equispaced circadian times (00:00, 06:00, 12:00 and 18:00 h), f...