EFFECT OF CAFFEINE ON PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS: A CASE STUDY OF PANADOL EXTRA

📄 Project Abstract

Acetaminophen or paracetamol is an analgesic and anti-pyretic agent widely used for treatment of headaches, minor pains and in combination with other medications like cold remedies and opoid analgesics. Individuals with headaches and minor pains tend to use paracetamol with caffeine combinations than paracetamol alone in their treatment due to faster relief. However, the pharmacokinetic rationale for use is still unclear. The aim of this study was to determine the effect of caffeine on pharmacokinetics of paracetamol in Panadol Extra(R) tablets using healthy human volunteers. Three different batches of Panadol(R) and Panadol Extra(R) tablets sourced from retail outlets within Zaria were analysed qualitatively using in vitro analysis which include weight uniformity test, friability test, chemical assay, dissolution test, disintegration test and also for the pharmacokinetic studies. Standard paracetamol powder was used for pilot study and to validate the modification of Glynn and Kendal ...