EFFECT OF AQUEOUS ETHANOL LEAF EXTRACT OF COMBRETUM MICRANTHUM G. DON (COMBRETACEAE) ON SOME INDUCED SYSTEMIC INFLAMMATORY IMMUNE RESPONSE SYNDROMES IN MICE AND RATS

📄 Project Abstract

The cellular immunity is often suppressed by infection, disease conditions and drug medication that are in continous association with mankind. Combretum micranthum is a plant known for its antioxidant, antimicrobial, anti-inflammatory and various other properties of immune boosting activity. The Plant extract was assessed for its ability to protect from tissue destruction. The aqueous ethanol leaf extract was screened for previously reported phytoconstituents; Lorke,s method of 1983 was used to determined the LD50 in mice and rats using both i.p. and oral routes. Effect of the extract on haematological parameters were assessed pre- Cyclophosphamide (200 mg/kg i.p) induction on the 10th day and three days post induction according to Thatte et al. (1987) in four groups (n=5) of wistar rats. Group I received (1 ml/kg distilled water) while group II, III and IV received (50, 100 and 200 mg/kg of extract) respectively. The protective effect of the extract was also performed according to Pal...