EFFECT OF AQUEOUS AND ETHANOLIC EXTRACT OF Alafia barteri LEAF ON OXIDATIVE STRESS PARAMETERS IN FORMALIN INDUCED PAW INFLAMMATION IN WISTAR RATS

📄 Project Abstract

This research analyzes the anti-oxidant impact of the aqueous and ethanolic leaf extract of Alafia barteri on the basis of their medicinal use in the therapy of inflammation,toothaches and fevers. The findings of the phytochemical testing showed that the extract contained alkaloids, steroids, saponins, flavonoids, phenolics and terpenoids which have been connected with anti-inflammatory actions.Ethanolic extract of A.barteri at the dose of 200 mg/kg and 400 mg/kg showed a substantial decrease in paw oedema rats volume when compared to the standard drug(diclofenac sodium 10mg/kg).The results support the traditional use of A. barteri in the therapy of mutiple pain and inflammation-related illnesses. A. barteri caused a major shift in the growth of paw oedema in the formalin induced.This study aimed at evaluating oxidative stress in the liver of formaldehyde-induced rats to cause paw inflammation. SOD, Catalase levels were calculated in the total liver homogenate and in addition to the ef...