Comparative Effects Of Nigella Sativaseed Oil And Zinc Gluconate Onethanol-Induced Gastric Mucosal Damage And Secretion In Wistar Rats

📄 Project Abstract

A wide spread search has been launched to identify new anti-ulcer therapies from natural sources, with minimal side effects. The aim of the study was to compare the effects of Nigella sativaseed oil and zinc gluconate on ethanol-induced gastric mucosal damage and secretion in Wistar rats. A total of 50 male rats, weighing between 150-200g were used for the study. The animals were then sub-divided into two sub-groups of 25 rats each for gastric mucosal damage and gastric secretion studies respectively. Each of the sub-groups were divided into 5 groups of 5 rats each and treated with distilled water (10ml/kg), absoluteethanol (1ml/kg),Nigella sativa oil (5ml/kg), zinc gluconate (50mg/kg) and zinc gluconate (50mg/kg) plus Nigella sativa oil (5ml/kg) respectively. The phythochemical screening of the Nigella sativa oil revealed the presence of carbohydrate, unsaturated steroids, triterpenes, cardiac glycoside and flavonoids. The results of the study revealed the normal architecture of gastr...