COMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITIS.

📄 Project Abstract

Tinea capitis is a fungal infection of the scalp and hair caused by dermatophytes. It occurs in all age groups but predominantly found in children. The antifungal activities such as MIC, MFC and rate of kill of fluconazole, terbinafine, lauric acid and sodium propionate alone and in admixture against dermatophyte isolates from school children with tinea capitis in L. E. A. primary school, Mando, Kaduna, Nigeria were assessed. T. mentagrophyte, T. tonsuran, T. rubrum, Trichophyton species M. canis, P. furfur. P. hortei were isolated from the school children. The trichophyton species had the highest order of prevalence (56.67%) followed by P. furfur (20%) while P. hortei was (13.33%) and M.canis was (10%). The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration (MFC) of fluconazole ranges were (0.5- 1.0mg/ml) and (1.00 - 8.00mg/ml) respectively against the test organisms. T. mentagrophyte (isolate number 18) was found to be the most resistant of the organisms ...