CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS
📄 Project Abstract
Diabetic complications pose increasing public health problems worldwide. Glimepiride, a sulphonylurea is among the most frequently used anti-diabetic drugs, and is often combined with other drugs for the management of type 2 diabetes mellitus. Nifedipine, a calcium channel blocker is recommended for its role in mitigating microvascular complications especially in delaying the onset of diabetic nephropathy. Interaction between both drugs leads to regimen failure when simultaneously administered. However, established diurnal variation in nifedipine pharmacokinetics can ameliorate the benefits of nifedipine-glimepiride co-administration. This study investigates the effect of 21-day chronomodulated nifedipine administration on glycaemic control and microvascular complications in glimepiride-treated streptozotocin-induced hyperglycaemic rats. All animals were treated daily per oral. Fasting and random blood glucose were assessed on days 0, 3, 7, 14, 21, and days 0, 6, 10, 13 20 respectively...
🔍 Key Research Areas Covered
- ✅ Literature Review & Theoretical Framework
- ✅ Research Methodology & Data Collection
- ✅ Data Analysis & Statistical Methods
- ✅ Findings & Results Discussion
- ✅ Recommendations & Conclusions
- ✅ References & Bibliography
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- Problem Statement & Objectives
- Theoretical Framework & Related Studies
- Data Collection & Analysis Methods
- Findings & Statistical Analysis
- Recommendations & Future Research
- Questionnaires, Data, References
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CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS
Full Citation:
Michael Ikechukwu Oraebosi. (). CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS. African and General Studies, 40, 14858.
Citation Formats:
APA
Michael Ikechukwu Oraebosi. (). CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS. African and General Studies, 40, 14858.
MLA
Michael Ikechukwu Oraebosi. "CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS." African and General Studies, vol. 40, , pp. 14858.
Chicago
Michael Ikechukwu Oraebosi. "CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS." African and General Studies 40 (): 14858.
Full Citation:
Michael Ikechukwu Oraebosi. (). CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS. African and General Studies, 40, 14858.
Citation Formats:
APA
Michael Ikechukwu Oraebosi. (). CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS. African and General Studies, 40, 14858.
MLA
Michael Ikechukwu Oraebosi. "CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS." African and General Studies, vol. 40, , pp. 14858.
Chicago
Michael Ikechukwu Oraebosi. "CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS." African and General Studies 40 (): 14858.
Document Details
| Author | Michael Ikechukwu Oraebosi |
|---|---|
| 📁 Field | Pharmacology And Therapeutics Project Topics |
| 🏷️ Type | Pharmaceutical Sciences Project Topics |
| Pages | 113 Pages |
| Words | 19612 words |
| 📘 Chapters | 1 to 5 Chapters |