Biochemical Analyses Of Free, Complexed, And Total Prostate Specific Antigen In Benign Prostatic Hyperplasia And Prostate Cancer In The University Of Calabar Teaching Hospital, Calabar.

📄 Project Abstract

The study exploited adjunct tests of molecular components of prostate specific antigen (i.e. free and complexed) to establish their clinical usefulness in the diagnosis of Benign Prostatic Hyperplasia (BPH) and Prostate Cancer (PCa). Method It was a cross sectional descriptive study involving 120 male participants between the ages of 40 and 80 years. They were consecutively recruited from the Urology Clinic of the University of Calabar Teaching Hospital. The study lasted for a period of twelve months. Participants were stratified into two groups of 60 each with histologically confirmed diagnosis of PCa and BPH respectively. Their sera were analysed for free, complexed, and total PSA using ELISA kits and read off with AWARENESS stat fax 2100 model microplate reader. Results Total Prostate Specific Antigen (tPSA) values were significantly lower in BPH than in PCa with median values of 8.4 ng/ml and 19.3 ng/ml respectively. Levels of fPSA were significantly higher in BPH with median value...