Assessment Of Some Prothrombotic Acute Phase Reactants In Hiv Infected Nigerians

📄 Project Abstract

HIV infection is known to increase the risk of venous thromboembolism by 2 to 10 folds. Studies have included the traditional risk factors such as prolonged ill health, hospitalization, infection and the use of protease inhibitors as possible causes. HIV infection being a chronic inflammatory disease induces a derangement in the levels of positive and negative acute phase reactants which may contribute to endothelial cell dysfunction thus increasing thromboembolic risk. This study aimed to evaluate acute phase reactants antithrombin and plasminogen activator inhibitor-1 (PAI-1) as markers of increased predisposition to thrombosis in HIV infected persons and comparing their levels with D-dimer levels- a marker of fibrinolysis and with fibrinopeptides A and B- markers of thrombogenesis. The presence (or not) of asymptomatic thrombosis in both lower limbs of HIV infected persons using Doppler ultrasonography was also determTo document the presence of asymptomatic thrombosis in both lower ...