Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja
📄 Project Abstract
HER2 positive breast cancers are characterised by over-expression and/or amplification of the HER2 gene and have a poor prognosis. However, treatment with anti-HER2 antibodies significantly alters the course of the disease. The most widely accepted methods for assessing HER2 status are immunohistochemistry (IHC) for protein expression and in situ hybridization (ISH) for detecting gene amplification. Most centres in this country utilise only IHC in determining HER2 status and due to its limitations, may result in false negative results. Additionally, there is no alternative test to re-assess equivocal cases. This study aimed to compare HER2 expression by IHC with HER2 gene amplification, to determine the clinicopathologic characteristics of breast cancer and correlation between these and HER2 status. Dual probe (PathVysion HER2 DNA probe kit) FISH was done assessing the ratio of HER-2/neu and chromosome 17 centromere signal counts. IHC was done using Novocastra antibody and scored based...
🔍 Key Research Areas Covered
- ✅ Literature Review & Theoretical Framework
- ✅ Research Methodology & Data Collection
- ✅ Data Analysis & Statistical Methods
- ✅ Findings & Results Discussion
- ✅ Recommendations & Conclusions
- ✅ References & Bibliography
📚 Complete Project Structure
- Problem Statement & Objectives
- Theoretical Framework & Related Studies
- Data Collection & Analysis Methods
- Findings & Statistical Analysis
- Recommendations & Future Research
- Questionnaires, Data, References
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Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja
Full Citation:
Aisha Nabila Wanka. (). Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja. African and General Studies, 40, 14858.
Citation Formats:
APA
Aisha Nabila Wanka. (). Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja. African and General Studies, 40, 14858.
MLA
Aisha Nabila Wanka. "Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja." African and General Studies, vol. 40, , pp. 14858.
Chicago
Aisha Nabila Wanka. "Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja." African and General Studies 40 (): 14858.
Full Citation:
Aisha Nabila Wanka. (). Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja. African and General Studies, 40, 14858.
Citation Formats:
APA
Aisha Nabila Wanka. (). Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja. African and General Studies, 40, 14858.
MLA
Aisha Nabila Wanka. "Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja." African and General Studies, vol. 40, , pp. 14858.
Chicago
Aisha Nabila Wanka. "Assessment Of Her2 Status In Female Breast Cancer: Comparison Of Fluorescence In Situ Hybridization And Immunohistochemistry, In National Hospital Abuja." African and General Studies 40 (): 14858.
Document Details
| Author | Aisha Nabila Wanka |
|---|---|
| 📁 Field | Anatomic Pathology project topics |
| 🏷️ Type | Medicine Project topics |
| Pages | 84 Pages |
| Words | 17045 words |
| 📘 Chapters | 1 to 5 Chapters |