ANTIMALARIAL AND ANTIOXIDANT EFFECTS OF METHANOL AND FLAVONOID-RICH EXTRACTS OF Adansonia digitata STEM BARK ON Plasmodium berghei-INFECTED MICE

📄 Project Abstract

Adansonia digitata has popular ethnomedicinal application in the treatment of malaria in sub-Saharan Africa. The present study sought to investigate the antimalarial and antioxidant effects of methanol and flavonoid-rich extracts of the stem bark on Plasmodium berghei-infected mice in vivo. Thirty-five male mice, weighing 18-20 g and randomly allocated into seven groups of five animals each were used. Group 1, which served as the positive control, was pretreated with 1 ml/kg of the vehicle (5% v/v tween 80), mice in groups 2 and 3 were pretreated with 5 mg/kg b.wt of the standard drugs: chloroquine and arthemter/lumfantrine respectively, groups 4 and 5 were pretreated with 200mg/kg and 400 mg/kg methanol extract of A. digitata (ADME) respectively while groups 6 and 7 were administered 200mg/kg and 400 mg/kg flavonoid-rich extract of A. digitata (ADFE)respectively. Drugs were administered by oral gavage once daily for five consecutive days before intraperitonial transfection of mice wit...