Anti-Hyperlipidemic Potential Of Vitex Donianaethanolextracts On Poloxamer 407 Induced Hyperlipidemic And Normal Rats

📄 Project Abstract

Anti-hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root bark on poloxamer 407 induced hyperlipidemic and normal rats was investigated. Phytochemical screening of the extracts revealed the presence of flavonoids, saponins, cardiac glycosides, alkaloids and tannins in the leaves, stem bark and root bark. The average total polyphenol contents of the leaves ethanol (36.11±3.13mg/g gallic acid) and methanol (35.75±1.72mg/g gallic acid) extracts were significantly (p<0.05) higher when compared with that of acetone and aqueous extracts. The IC50of the leaves ethanol extract (0.227mg/ml) was lowerthan that ofstem bark ethanol extract (0.236mg/ml) and root ethanol extract (0.561mg/ml). Screening the extracts for the most potent anti-hyperlipidemicactivityreveals that ethanolic extracts of root bark and leaveshas the highest percentage reduction of total cholesterol (51.98%) and triacylglycerol (50.75%) respective...