Angiotensin Converting Enzyme Activity In Type 2 Diabetes Mellitus Patients In University Of Port Harcourt Teaching Hospital, Port Harcourt

📄 Project Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disorder, in which poor glycaemic control results in complications such as hypertension and nephropathy with dyslipidaemia as a risk factor. Hyperglycaemia causes altered lipid metabolism (dyslipidaemia) with the formation of advanced glycation end products (AGEs) and protein kinase C (PKC), which accelerate atherosclerosis and alter gene transcription for contractile protein respectively, with eventual stiffening of the vascular wall leading to hypertension. The rising prevalence of diabetes in Nigeria, and Africa requires critical attention in the patient management. Angiotensin converting enzyme (ACE) regulates blood pressure, and its increased activity results in vascular complications which are also implicated in DM. This study measured and compared the serum angiotensin converting enzyme (ACE) activity in: (1) a group of type 2 diabetics with healthy (control) subjects, (2) diabetics without hypertension and diabetics with...