Ameliorative Effects Of Fractionated Extracts Of Vitex Simplicifolia Leaf On Blood Glucose And Some Physiological Parameters In Alloxan- Induced Diabetic Wistar Rats

📄 Project Abstract

Herbal medicine is the oldest form of health care known to mankind. A concoction of Vitex simplicifolia leaf is widely used in sub Saharan Africa for treatment of diabetes mellitus and a lot other diseases. The study investigated the hypoglycemic, hypolipidemic, antioxidant and hepato-renal toxicity of fractionated extract of Vitex simplicifolia leaf on alloxan-induced diabetic rats. The plant extract was fractionated in solvents of varying polarities (aqueous, methanolic, hexane and ethyl acetate). 250, 500 and 1000mg/kg of body weight of the fractionated extracts were administered to the diabetic rats, aqueous (groups 4, 5 and 6), methanolic (groups 7, 8 and 9), ethyl acetate (groups 10, 11 and 12), hexane (groups 13, 14 and 15). Groups 1 and 2 were normal and diabetic control, while group 3 was administered glibenclimade (reference drug). Fasting blood glucose, lipid profile, liver glycogen content, superoxide dismutase (SOD), vitamins A, C and E, AST, ALP, ALT, unconjugated bilirub...