Ameliorative Effects Of Aqueous Extracts Of Brysocarpus Coccineus On Isoniazid Induced Oxidative Stress And Hepatotoxicity In Adult Male Wistar Rats

📄 Project Abstract

Tuberculosis is the most common cause of death from an infectious agent, it is an important cause of morbidity and mortality in Africa and Nigeria. Isoniazid (INH) is one of the effective drugs used in its treatment and prevention with the inadvertent complications of oxidative stress and hepatotoxicity. The aim of the current study was to determine the antioxidant and hepatoprotective effects of Brysocarpus coccineus aqueous extracts on isoniazid induced oxidative stress and hepatotoxicty. Adult male Wistar rats were divided into six groups of five rats each and treated orally for 30 days as follows: Group I: 1 ml/kg of distilled water; group II: Isoniazid (27 mg/kg); group III: Isoniazid (27 mg/kg) + Livolin forte (20 mg/kg); group IV: Isoniazid (27 mg/kg) + B. coccineus (200 mg/kg); group V: Isoniazid (27 mg/kg) + B. coccineus (400 mg/kg); group VI: Isoniazid (27 mg/kg) + B. coccineus (800 mg/kg). Afterwards rats were sacrificed and serum was collected for oxidative stress and hepat...