Ameliorative Effect of Ethanoic Extract of Vernonia amygdalina (Del) Leaves on Reproductive Functions of Letrozole-induced Polycystic Ovarian Syndrome in Wistar Rats

📄 Project Abstract

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder known by symptoms such as hyperandrogenism, amenorrhea, and polycystic ovaries. Being an endocrine disorder, its associated with metabolic dysfunction of the endocrine gland which results to an imbalance of the sex hormones which include reduced level of follicle stimulating hormone and progesterone increased level of luteinizing hormone, Insulin and testosterone which causes cyst to form in the antral ovarian follicle. Among the various reference drugs used in the treatment of PCOS combination of metformin with clomiphene citrate used in this study, has shown to exhibit a good therapeutic effect in the management of PCOS. Ethnomedicine such as Parquetina nigrescens leaves, Aspargus Racemosus, Tinospora Cordifolia etc. have been reported to contain phytocompounds which showed therapeutic effect in annulling the comorbidities associated with PCOS. Therefore, this study was aimed at evaluating the ameliorative effect of ethanoic e...