A Study Of D-Dimer And Some Fibrinolytic Proteins In Patients With Sickle Cell Anaemia In Steady State And In Vaso Occlusive Crisis At Lagos University Teaching Hospital (Luth)

📄 Project Abstract

Sickle cell anaemia has been described as a hypercoagulable state. A number of coagulation abnormalities as well as abnormalities in fibrinolysis have been described in this disorder. However, whether the activation of blood coagulation and fibrinolysis is contributory to vaso-occlusive crisis is unknown and therefore the predictive value of these coagulant and fibrinolytic proteins in determining the onset of vaso-occlusive crisis has not been documented. This study therefore aims to determine the plasma concentration of some fibrinolytic proteins (D-dimer, Plaminogen, Tissue Plasminogen Activator) and coagulant proteins;(Fibrinogen and Fibrinopeptide A) in sickle cell anaemia patients in both steady state and in vaso-occlusive crisis for the purpose of determining their clinical value in assessing and/or predicting the onset of vaso-occlusive. Study Design: This is a two -arm cross-sectional descriptive study conducted on sickle cell anaemia patients in steady states (Arm 1) and in v...