A Cross Sectional Study Of Antiphospholipid Antibody Levels In Patients With Type 2 Diabetes Mellitus In Enugu, South-East Nigeria.

📄 Project Abstract

BACKGROUND: Antiphospholipid antibodies (APLS) are group of acquired, heterogeneous, autoimmune antibodies that bind to phospholipid(s), phospholipid - binding proteins or both. Antiphospholipid antibodies are associated with thrombosis (arterial, venous or both). Type 2 - diabetes mellitus is the commonest type of diabetes mellitus, characterised by hyper-glycaemia due to relative insulin deficiency or insulin resistance, or both. Type 2 - diabetes mellitus predisposes to arterial thrombosis, with wide range of ischaemic thrombosis, with the manifestation of TIA and stroke, nephropathy, retinopathy, neuropathy, platelet abnormalities, hypertension and other complications. OBJECTIVE: To detect and assess the prevalence of antiphospholipid antibodies in subjects with type 2 diabetes mellitus. METHODOGY: This was a cross -sectional study carried out on subjects with T2DM attending the diabetic clinic of University of Nigeria Teaching Hospital (UNTH), Ituku - Ozalla, Enugu, South - East N...