ABSTRACT
Diabetes is a major threat to global public health, and the numbers of diabetic patients are rapidly increasing world-wide. This study was aimed at determining the serum electrolyte concentration and glycosylated haemoglobin level of diabetic patients and apparently healthy individuals. A total of one hundred and twenty (120) subjects were used for the study. Seventy (70) subjects (apparently healthy) aged between 38 and 60 years with no history of diabetes mellitus or any other hyperglycaemic disorder served as the control group while fifty (50) subjects of both genders (38-60 years) represented those with known history of diabetes mellitus . The subjects were divided into five (5) groups. Group 1 represents diabetic subjects with genotype AA, group 2 represents non-diabetic subjects with genotype AS, group 5 represents non diabetic subjects with genotype SS, group 3 represents diabetic subjects on treatment with genotype AA while group 4 represents diabetic subjects on treatment with genotype AS. All subjects used were residents within and around the environs of Gwagwalada, Gwagwalada Area Council of the Federal Capital Territory, Abuja. The duration of the experiment was two (2) months. Blood samples from all subjects were obtained by venipuncture from the anticubital vein into plain bottles. The blood was allowed to clot and then centrifuged for 10 min at 3000 rpm. The separated serum was stored in a freezer at 2-80C till the time of use. Whole blood for determination of genotype and glycosylated haemoglobin was obtained by venipuncture from the anticubital vein into an EDTA container. The samples were kept in the refrigerator at 2–8 0c till the time of use. The result showed a significant decrease (p<0 .05="" 1="" 3="" 4="" 5="" a="" aa="" and="" as="" compared="" concentration="" diabetic="" exhibited="" genotype="" group="" groups="" in="" increase="" individuals="" ion="" na="" non-significant="" normal="" of="" p="" patients="" representing="" serum="" sodium="" ss="" subjects="" the="" with="">0.05) in the Na+ concentration compared with that of AA and AS diabetic patients on treatment in groups 3 and 4. There was significant (p<0 .05="" 2.="" 3="" 4="" 5="" aa="" and="" as="" chloride="" compared="" concentration="" contained="" decreased="" diabetic="" elevation="" groups1="" groups="" however="" in="" ion="" k="" l="" non-significant="" normal="" of="" on="" p="" patients="" potassium="" represented="" respectively="" significantly="" ss="" subjects.="" subjects="" the="" treatment="" which="" with="">0.05) variations were observed in the Cl– concentration of AA, AS and SS normal subjects when compared with their AA, AS diabetic subjects on treatment. Significant decrease (p<0 .05="" aa="" and="" as="" bicarbonate="" compared="" concentration="" diabetic="" difference="" glycosylated="" hand="" hco3="" hemoglobin="" in="" increased="" ion="" level="" non-significant="" normal="" observed="" of="" on="" other="" p="" significantly="" ss="" subjects.="" subjects="" that="" the="" there="" treatment="" was="" with="">0.05) in the level of glycated haemoglobin in AA, AS and SS normal subjects. It was observed from the result of the present study that the serum electrolyte (sodium, potassium, chloride and bicarbonate) and glycosylated haemoglobin concentrations showed significant difference (p<0 .05="" accordance="" be="" can="" could="" diabetic="" for="" from="" genotype.="" glycosylated="" haemoglobin="" in="" irrespective="" management="" mellitus="" of="" patients.="" patients="" predictive="" said="" study="" the="" this="" to="" utilized="" value="" with=""> 6.0 %.
<0 .05="" 1="" 3="" 4="" 5="" a="" aa="" and="" as="" compared="" concentration="" diabetic="" exhibited="" genotype="" group="" groups="" in="" increase="" individuals="" ion="" na="" non-significant="" normal="" of="" p="" patients="" representing="" serum="" sodium="" ss="" subjects="" the="" with=""><0 .05="" 2.="" 3="" 4="" 5="" aa="" and="" as="" chloride="" compared="" concentration="" contained="" decreased="" diabetic="" elevation="" groups1="" groups="" however="" in="" ion="" k="" l="" non-significant="" normal="" of="" on="" p="" patients="" potassium="" represented="" respectively="" significantly="" ss="" subjects.="" subjects="" the="" treatment="" which="" with=""><0 .05="" aa="" and="" as="" bicarbonate="" compared="" concentration="" diabetic="" difference="" glycosylated="" hand="" hco3="" hemoglobin="" in="" increased="" ion="" level="" non-significant="" normal="" observed="" of="" on="" other="" p="" significantly="" ss="" subjects.="" subjects="" that="" the="" there="" treatment="" was="" with=""><0 .05="" accordance="" be="" can="" could="" diabetic="" for="" from="" genotype.="" glycosylated="" haemoglobin="" in="" irrespective="" management="" mellitus="" of="" patients.="" patients="" predictive="" said="" study="" the="" this="" to="" utilized="" value="" with="">| Review project details | Comments |
|---|---|
| Number of Pages | 62 pages |
| Chapter one (1) | Yes Introduction |
| Chapter two (2) | Yes Literature review |
| Chapter three (3) | Yes methodology |
| Chapter four (4) | Yes Data analysis |
| Chapter five (5) | Yes Summary,discussion & recommendations |
| Reference | Yes Reference |
| Questionnaire | Yes Questionnaire |
| Appendix | yes Appendix |
| Chapter summary | yes 1 to 5 chapters |
| Available document | PDF and MS-word format |
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