ABSTRACT
A comparative study of the effects of aqueous extract of Moringa oleifera and Vernonia amygdalina on selected biochemical indices of prostate pathologies of male albino rats was investigated using thirty two adult male albino rats of average weight of 152g. Rats were randomly assigned into four groups of eight rats each with different recognizable codes. Group one served as the control and each rat in this group received orally 2ml of distill water daily. Groups two and three received oral administrations of 2ml aqueous extract containing 5g of M. oleifera, V. amygdalina respectively daily. Group four received 4ml containing 2.5g of M. oleifera with 2.5g of V. amygdalina per body weight orally daily. Administration of the extract was done for 28 days. The rats were fed on growers match and tap water ad libitum throughout the experiment. The animals were housed in standard animal cages in the animal house of the Department of Biochemistry, Kogi State University, Anyigba under 12 hour light/ dark cycle for 29 days. Changes in weight were noted at the end of every week for the four weeks. The animals were starved over-night and blood drawn from cut at the tip of the tails was used for fasting blood glucose test. All the animals were killed on the 29th day by jugular puncture; part of their blood was collected into plain bottle and spun to obtain serum, and part into EDTA bottle for biochemical analyses. A non significant weight increase was observed till the third week of administration of the extract followed by a decrease in weight in the fourth week. The group administered a combination of the extracts of M. oleifera with V. amygdalina showed a significant decrease (P<0 .05="" a="" administered="" all="" alone="" amygdalina="" an="" and="" blood="" but="" cell="" combination="" compared="" control.="" control="" fasting="" glucose="" group="" groups="" in="" increase="" m.="" not="" of="" oleifera="" p="" packed="" recorded="" reduction="" significant="" the="" to="" v.="" value.="" volume="" was="" were="" when="" with="">0.05). A significant increase in the total protein was recorded for the group administered V. amygdalina and the combination of M. oleifera with V. amygdalina. A significant increase (p<0 .05="" a="" administered="" albumin="" all="" amygdalina="" an="" and="" bilirubin="" but="" combination.="" combination="" compared="" concentration="" control="" decreased="" electrolyte="" equivalent="" for="" globulin="" group="" groups="" in="" increase="" increased="" ion="" level="" m.="" not="" observed="" of="" oleifera="" only="" p="" potassium="" relative="" respectively.="" respectively="" serum="" significant="" the="" there="" to="" urea="" v.="" value.="" was="" when="">0.05) when compared to the control value. Both plant leaf extracts reduced the serum chloride ion but the combination did it better. M. oleifera recorded a significant reduction in serum sodium ion compared to V. amygdalina and the combination but their differences was not significant (P>0.05). For serum lipid profile, V. amygdalina has a significant reduction (p<0 .05="" amygdalina="" and="" but="" cholesterol.="" combination="" compared="" for="" hdl="" increased="" m.="" not="" oleifera="" over="" potential="" significant="" the="" to="" total="" v.="">0.05). LDL decreased significantly (P
<0 .05="" a="" administered="" all="" alone="" amygdalina="" an="" and="" blood="" but="" cell="" combination="" compared="" control.="" control="" fasting="" glucose="" group="" groups="" in="" increase="" m.="" not="" of="" oleifera="" p="" packed="" recorded="" reduction="" significant="" the="" to="" v.="" value.="" volume="" was="" were="" when="" with=""><0 .05="" a="" administered="" albumin="" all="" amygdalina="" an="" and="" bilirubin="" but="" combination.="" combination="" compared="" concentration="" control="" decreased="" electrolyte="" equivalent="" for="" globulin="" group="" groups="" in="" increase="" increased="" ion="" level="" m.="" not="" observed="" of="" oleifera="" only="" p="" potassium="" relative="" respectively.="" respectively="" serum="" significant="" the="" there="" to="" urea="" v.="" value.="" was="" when=""><0 .05="" amygdalina="" and="" but="" cholesterol.="" combination="" compared="" for="" hdl="" increased="" m.="" not="" oleifera="" over="" potential="" significant="" the="" to="" total="" v.=""><0 .05="" a="" acid="" activities="" and="" associated="" combined="" compared="" control="" decreases="" disorders="" div="" entire="" extract="" factors="" group="" however="" in="" intervention="" markers="" metabolic="" p="" pap="" phosphatase="" plants="" potential="" prostate="" prostatic="" recorded="" reduction="" relative="" showed="" significant="" single.="" style="text-align: justify;" tap.="" the="" their="" to="" total="" two="" value.="" were="" when="" with="">| Review project details | Comments |
|---|---|
| Number of Pages | 83 pages |
| Chapter one (1) | Yes Introduction |
| Chapter two (2) | Yes Literature review |
| Chapter three (3) | Yes methodology |
| Chapter four (4) | Yes Data analysis |
| Chapter five (5) | Yes Summary,discussion & recommendations |
| Reference | Yes Reference |
| Questionnaire | Yes Questionnaire |
| Appendix | yes Appendix |
| Chapter summary | yes 1 to 5 chapters |
| Available document | PDF and MS-word format |
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